Canine Ras-responsive element-binding protein 1 (RREB1) ELISA Kit | RREB1 elisa kit
Canine Ras-responsive element-binding protein 1 (RREB1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Description
RREB1: Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; DNA-binding; Transcription, coactivator/corepressor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: nucleoplasm; nuclear body; cytoplasm; nucleolus; nuclear speck; nucleus
Molecular Function: metal ion binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; positive regulation of mammary gland epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter