Canine Cytochrome P450 2C8 (CYP2C8) ELISA Kit | CYP2C8 elisa kit

Canine Cytochrome P450 2C8 (CYP2C8) ELISA Kit

Cat. Num. AAA7243513

• Gene Names: CYP2C8; CPC8; CYPIIC8; MP-12/MP-20
• Reactivity: Canine
• Synonyms: Cytochrome P450 2C8 (CYP2C8); Canine Cytochrome P450 2C8 (CYP2C8) ELISA Kit; CYP2C8 elisa kit

• Reactivity: Canine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 5.0-100ng/mL
• Sensitivity: 1.0ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 98991773
• NCBI GeneID: 1558
• NCBI Accession #: NP_000761.3
• NCBI GenBank Nucleotide #: NM_000770.3
• Molecular Weight: 44,358 Da
• NCBI Official Full Name: cytochrome P450 2C8 isoform a
• NCBI Official Synonym Full Names: cytochrome P450, family 2, subfamily C, polypeptide 8
• NCBI Official Symbol: CYP2C8
• NCBI Official Synonym Symbols: CPC8; CYPIIC8; MP-12/MP-20
• NCBI Protein Information: cytochrome P450 2C8; P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrome P450 form 1; microsomal monooxygenase; xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
• UniProt Protein Name: Cytochrome P450 2C8
• Protein Family: Cytochrome
• UniProt Gene Name: CYP2C8
• UniProt Entry Name: CP2C8_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

CYP2C8: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity

Biological Process: organic acid metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process; epoxygenase P450 pathway; drug metabolic process