Canine CD2-associated protein (CD2AP) ELISA Kit | CD2AP elisa kit
Canine CD2-associated protein (CD2AP) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
Uniprot Description
CD2AP: an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3).
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: filamentous actin; ruffle; cytoplasm; plasma membrane; nucleolus; intercellular junction; actin cytoskeleton
Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding
Biological Process: mitosis; cell division; protein complex assembly; signal transduction; substrate-bound cell migration, cell extension; negative regulation of transforming growth factor-beta1 production
Disease: Focal Segmental Glomerulosclerosis 3, Susceptibility To
Research Articles on CD2AP
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Product Notes
The Canine CD2AP cd2ap (Catalog #AAA7211492) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7211492 ELISA Kit recognizes Canine CD2AP. It is sometimes possible for the material contained within the vial of "CD2-associated protein (CD2AP), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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