Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) Recombinant Protein | CACNA1C recombinant protein
Recombinant Guinea pig Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)
NCBI and Uniprot Product Information
Uniprot Description
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function
By similarity.
Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CACNA2D4
By similarity. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane
By similarity. Note: The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane
By similarity.
Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel
By similarity.
Post-translational modification: Phosphorylation by PKA activates the channel
By similarity.
Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]
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Product Notes
The Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) cacna1c (Catalog #AAA1217191) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-169. The amino acid sequence is listed below: FQEQGEQEYK NCELDKNQRQ CVEYALKARP LRRYIPISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQVFGKIA LNDTTEINRN NNFQTFPQAV LLLFRCATGE AWQDIMLACM PGKKRAPESE PSNSTEGETP CGSSFAVFY. It is sometimes possible for the material contained within the vial of "Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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