Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) Recombinant Protein | CACNA1A recombinant protein
Recombinant Human Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) , partial
NCBI and Uniprot Product Information
NCBI Description
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Uniprot Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Research Articles on CACNA1A
Similar Products
Product Notes
The CACNA1A cacna1a (Catalog #AAA1234559) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 714-1241aa; Partial. The amino acid sequence is listed below: DNLANAQELT KDEQEEEEAA NQKLALQKAK EVAEVSPLSA ANMSIAVKEQ QKNQKPAKSV WEQRTSEMRK QNLLASREAL YNEMDPDERW KAAYTRHLRP DMKTHLDRPL VVDPQENRNN NTNKSRAAEP TVDQRLGQQR AEDFLRKQAR YHDRARDPSG SAGLDARRPW AGSQEAELSR EGPYGRESDH HAREGSLEQP GFWEGEAERG KAGDPHRRHV HRQGGSRESR SGSPRTGADG EHRRHRAHRR PGEEGPEDKA ERRARHREGS RPARGGEGEG EGPDGGERRR RHRHGAPATY EGDARREDKE RRHRRRKENQ GSGVPVSGPN LSTTRPIQQD LGRQDPPLAE DIDNMKNNKL ATAESAAPHG SLGHAGLPQS PAKMGNSTDP GPMLAIPAMA TNPQNAASRR TPNNPGNPSN PGPPKTPENS LIVTNPSGTQ TNSAKTARKP DHTTVDIPPA CPPPLNHTVV QVNKNANPDP LPKKEEEKKE EEEDDRGEDG PKPMPPYSSM FILSTTNPLR RLCHYILN . It is sometimes possible for the material contained within the vial of "Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
