Western Blot (WB)
(FBXW5 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FBXW5 antibody detected the FBXW5 protein (arrow).)
Rabbit anti-Human FBXW5 Polyclonal Antibody | anti-FBXW5 antibody
FBXW5 Antibody (Center)
Western Blot (WB)
(FBXW5 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FBXW5 antibody detected the FBXW5 protein (arrow).)
Western Blot (WB)
(FBXW5 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FBXW5 antibody detected the FBXW5 protein (arrow).)
members of which are characterized by an approximately 40 amino
acid motif, the F-box. The F-box proteins constitute one of the
four subunits of ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent
ubiquitination. The F-box proteins are divided into three classes:
Fbws containing WD-40 domains, Fbls containing leucine-rich
repeats, and Fbxs containing either different protein-protein
interaction modules or no recognizable motifs. The protein encoded
by this gene contains WD-40 domains, in addition to an F-box motif,
so it belongs to the Fbw class. Alternatively spliced transcript
variants encoding distinct isoforms have been identified for this
gene, however, they were found to be nonsense-mediated mRNA decay
(NMD) candidates, hence not represented.
Minoda, Y., et al. Biochem. Biophys. Res. Commun. 381(3):412-417(2009)
Hu, J., et al. Genes Dev. 22(7):866-871(2008)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Uniprot Description
FBXW5: Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Belongs to the FBXW5 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cytoplasm; SCF ubiquitin ligase complex
Molecular Function: protein binding; protein kinase binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; protein ubiquitination; centrosome duplication
Research Articles on FBXW5
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Product Notes
The FBXW5 fbxw5 (Catalog #AAA9202782) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 324-350. The FBXW5 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBXW5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the FBXW5 fbxw5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXW5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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