Human chromosome 6 open reading frame 150 ELISA Kit | C6orf150 elisa kit
Human Protein MB21D1, C6orf150 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
Protein type: Enzyme, cellular metabolism; EC 2.7.7.86
Chromosomal Location of Human Ortholog: 6q13
Cellular Component: cytosol
Molecular Function: DNA binding; GTP binding; metal ion binding; ATP binding
Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response
Research Articles on C6orf150
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Product Notes
The Human C6orf150 mb21d1 (Catalog #AAA9332833) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332833 ELISA Kit recognizes Human C6orf150. It is sometimes possible for the material contained within the vial of "chromosome 6 open reading frame 150, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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