C5a anaphylatoxin chemotactic receptor (C5ar1) Recombinant Protein | C5ar1 recombinant protein
Recombinant Rat C5a anaphylatoxin chemotactic receptor (C5ar1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
binds complement component 5 and induces Ca+2 release from intracellular stores [RGD, Feb 2006]
Uniprot Description
C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane
Molecular Function: C5a anaphylatoxin receptor activity; complement component C5a binding; complement component C5a receptor activity
Biological Process: apoptosis; cell proliferation in hindbrain; complement receptor mediated signaling pathway; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; inflammatory response; mRNA transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ regeneration; positive regulation of angiogenesis; positive regulation of epithelial cell proliferation; response to lipopolysaccharide; response to peptidoglycan
Research Articles on C5ar1
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Product Notes
The C5ar1 c5ar1 (Catalog #AAA7010590) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-352aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the C5ar1 c5ar1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDPISNDSSE ITYDYSDGTP NPDMPADGVY IPKMEPGDIA ALIIYLAVFL VGVTGNALVV WVTAFEAKRT VNAIWFLNLA VADLLSCLAL PILFTSIVKH NHWPFGDQAC IVLPSLILLN MYSSILLLAT ISADRFLLVF KPIWCQKFRR PGLAWMACGV TWVLALLLTI PSFVFRRIHK DPYSDSILCN IDYSKGPFFI EKAIAILRLM VGFVLPLLTL NICYTFLLIR TWSRKATRST KTLKVVMAVV TCFFVFWLPY QVTGVILAWL PRSSSTFQSV ERLNSLCVSL AYINCCVNPI IYVMAGQGFH GRLRRSLPSI IRNVLSEDSL GRDSKSFTRS TMDTSTQKSQ AV. It is sometimes possible for the material contained within the vial of "C5a anaphylatoxin chemotactic receptor (C5ar1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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