C4b-binding protein beta chain (C4BPB) Recombinant Protein | C4BPB recombinant protein

Recombinant Human C4b-binding protein beta chain (C4BPB)

Cat. Num. AAA958628

• Gene Names: C4BPB; C4BP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C4b-binding protein beta chain (C4BPB); Recombinant Human C4b-binding protein beta chain (C4BPB); C4BPB recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 18-252, Full length protein
• Sequence: SDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL
• Sequence Length: 235

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for C4BPB recombinant protein

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 4502505
• NCBI GeneID: 725
• NCBI Accession #: NP_000707.1
• NCBI GenBank Nucleotide #: NM_000716.3
• UniProt Accession #: P20851; Q5VVR0; Q9BS25; A5JYP8; D3DT81
• Molecular Weight: 28,286 Da
• NCBI Official Full Name: C4b-binding protein beta chain isoform 1
• NCBI Official Synonym Full Names: complement component 4 binding protein beta
• NCBI Official Symbol: C4BPB
• NCBI Official Synonym Symbols: C4BP
• NCBI Protein Information: C4b-binding protein beta chain
• UniProt Protein Name: C4b-binding protein beta chain
• Protein Family: C4b-binding protein
• UniProt Gene Name: C4BPB

NCBI Description

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.