C1QBP recombinant protein

C1QBP Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122608

• Gene Names: C1qbp; P32; HABP1; gC1qBP; AA407365; AA986492; D11Wsu182e
• Purity: >92% as determined by SDS-PAGE
• Synonyms: C1QBP; C1QBP Protein; Mouse; Recombinant (His Tag); Mouse HABP1/C1QBP Protein (His Tag); AA407365 Protein; AA986492 Protein; D11Wsu182e Protein; gC1qBP Protein; HABP1 Protein; P32 Protein; complement component 1; q subcomponent binding protein; C1QBP recombinant protein

• Host: E Coli
• Purity/Purification: >92% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Leu72-Gln279

• Species: Mouse
• Predicted N Terminal: Met
• Tag: N-His
• Protein Construction: A DNA sequence encoding the mature form of mouse C1QBP (NP_031599.2)(Leu 72-Gln 279) was expressed, with a polyhistide tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for C1QBP recombinant protein

Background: Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1)/p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner.

References

Meenakshi J, et al. (2003) Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochemicaland Biophysical Research Communication. 300(3): 686-93.Majumdar M, et al. (2002) Hyaluronan Binding Protein 1 (HABP1)/C1QBP/p32 Is an Endogenous Substrate for MAP Kinase and Is Translocated to the Nucleus upon Mitogenic Stimulation. Biochemical and Biophysical Research Communications. 291(4): 829-37.Ghosh I, et al. (2002) Reduction in the level of hyaluronan binding protein 1 (HABP1) is associated with loss of sperm motility. Journal of Reproductive Immunology. 53(1-2): 45-54.

NCBI and Uniprot Product Information

• NCBI GI #: 112181167
• NCBI GeneID: 12261
• NCBI Accession #: NP_031599.2
• NCBI GenBank Nucleotide #: NM_007573.2
• UniProt Accession #: O35658
• Molecular Weight: 31,013 Da
• NCBI Official Full Name: complement component 1 Q subcomponent-binding protein, mitochondrial
• NCBI Official Synonym Full Names: complement component 1, q subcomponent binding protein
• NCBI Official Symbol: C1qbp
• NCBI Official Synonym Symbols: P32; HABP1; gC1qBP; AA407365; AA986492; D11Wsu182e
• NCBI Protein Information: complement component 1 Q subcomponent-binding protein, mitochondrial
• UniProt Protein Name: Complement component 1 Q subcomponent-binding protein, mitochondrial
• Protein Family: Complement component 1 Q subcomponent-binding protein
• UniProt Gene Name: C1qbp
• UniProt Synonym Gene Names: Gc1qbp; C1qBP
• UniProt Entry Name: C1QBP_MOUSE