Human chromosome 1 open reading frame 124 ELISA Kit | C1orf124 elisa kit
Human Zinc finger RAD18 domain-containing protein C1orf124, C1orf124 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Description
SPRTN: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Also required for localization of DNA polymerase eta (POLH) to sites of UV damage. Belongs to the Spartan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 1q42.12-q43
Cellular Component: nucleoplasm; nuclear speck; chromosome; nucleus
Molecular Function: protein binding; ubiquitin binding; DNA binding; metal ion binding
Biological Process: bypass DNA synthesis; positive regulation of protein ubiquitination; response to DNA damage stimulus; response to UV
Disease: Ruijs-aalfs Syndrome
Research Articles on C1orf124
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Product Notes
The Human C1orf124 sprtn (Catalog #AAA9324762) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324762 ELISA Kit recognizes Human C1orf124. It is sometimes possible for the material contained within the vial of "chromosome 1 open reading frame 124, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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