Uncharacterized methyltransferase WBSCR22 (WBSCR22) Recombinant Protein | WBSCR22 recombinant protein

Recombinant Human Uncharacterized methyltransferase WBSCR22 (WBSCR22)

Cat. Num. AAA1173127

• Gene Names: BUD23; WBMT; MERM1; PP3381; HUSSY-3; WBSCR22; HASJ4442
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Uncharacterized methyltransferase WBSCR22 (WBSCR22); Recombinant Human Uncharacterized methyltransferase WBSCR22 (WBSCR22); WBSCR22 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-281, Full length protein
• Sequence: MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF
• Sequence Length: 281

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for WBSCR22 recombinant protein

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.

NCBI and Uniprot Product Information

• NCBI GI #: 321400149
• NCBI GeneID: 114049
• NCBI Accession #: NP_001189489.1
• NCBI GenBank Nucleotide #: NM_001202560.2
• UniProt Accession #: O43709; Q96P12; Q9BQ58; Q9HBP9; A8K501; C9K060
• Molecular Weight: 33,846 Da
• NCBI Official Full Name: probable 18S rRNA (guanine-N(7))-methyltransferase isoform 1
• NCBI Official Synonym Full Names: BUD23, rRNA methyltransferase and ribosome maturation factor
• NCBI Official Symbol: BUD23
• NCBI Official Synonym Symbols: WBMT; MERM1; PP3381; HUSSY-3; WBSCR22; HASJ4442
• NCBI Protein Information: probable 18S rRNA (guanine-N(7))-methyltransferase
• UniProt Protein Name: Probable 18S rRNA (guanine-N(7))-methyltransferase
• Protein Family: Probable 18S rRNA
• UniProt Gene Name: BUD23

NCBI Description

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011]

Uniprot Description

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N7 position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).