Human Basigin ELISA Kit | BSG elisa kit

Human Basigin ELISA Kit

Cat. Num. AAA9427848

• Gene Names: BSG; OK; 5F7; TCSF; CD147; EMMPRIN
• Reactivity: Human
• Synonyms: Basigin; Human Basigin ELISA Kit; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase; BSG elisa kit

• Reactivity: Human

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 78-5000 pg/mL
• Sensitivity: Less than 33pg/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 1016080631
• NCBI GeneID: 682
• NCBI Accession #: NP_001309172.1
• NCBI GenBank Nucleotide #: NM_001322243.1
• UniProt Accession #: P35613; Q7Z796; Q8IZL7; A6NJW1; D3YLG5
• Molecular Weight: 22,764 Da
• NCBI Official Full Name: basigin isoform 2
• NCBI Official Synonym Full Names: basigin (Ok blood group)
• NCBI Official Symbol: BSG
• NCBI Official Synonym Symbols: OK; 5F7; TCSF; CD147; EMMPRIN
• NCBI Protein Information: basigin
• UniProt Protein Name: Basigin
• Protein Family: Basigin
• UniProt Gene Name: BSG
• UniProt Synonym Gene Names: EMMPRIN; TCSF

NCBI Description

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: focal adhesion; Golgi membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; mitochondrion; plasma membrane

Molecular Function: cadherin binding; monocarboxylic acid transmembrane transporter activity; protein binding

Biological Process: cell surface receptor linked signal transduction; extracellular matrix disassembly; extracellular matrix organization and biogenesis; leukocyte migration; pyruvate metabolic process

Disease: Blood Group--ok