Bovine Caseinolytic peptidase B protein homolog (CLPB) ELISA Kit | CLPB elisa kit
Bovine Caseinolytic peptidase B protein homolog (CLPB) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
CLPB: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Belongs to the clpA/clpB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: mitochondrion
Molecular Function: ATP binding
Disease: 3-methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia
Research Articles on CLPB
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Product Notes
The Bovine CLPB clpb (Catalog #AAA7224200) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7224200 ELISA Kit recognizes Bovine CLPB. It is sometimes possible for the material contained within the vial of "Caseinolytic peptidase B protein homolog (CLPB), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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