Bovine Carbohyde sulfotransferase 4 (CHST4) ELISA Kit | CHST4 elisa kit

Bovine Carbohyde sulfotransferase 4 (CHST4) ELISA Kit

Cat. Num. AAA7250081

• Gene Names: CHST4; GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
• Reactivity: Bovine
• Synonyms: Carbohyde sulfotransferase 4 (CHST4); Bovine Carbohyde sulfotransferase 4 (CHST4) ELISA Kit; CHST4 elisa kit

• Reactivity: Bovine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for CHST4 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 262205558
• NCBI GeneID: 10164
• NCBI Accession #: NP_001159867.1
• NCBI GenBank Nucleotide #: NM_001166395.1
• Molecular Weight: 45,134 Da
• NCBI Official Full Name: carbohydrate sulfotransferase 4
• NCBI Official Synonym Full Names: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
• NCBI Official Symbol: CHST4
• NCBI Official Synonym Symbols: GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
• NCBI Protein Information: carbohydrate sulfotransferase 4; GST-3; gn6st-2; glcNAc6ST-2; HEC-GlcNAc6ST; L-selectin ligand sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 2; high endothelial cells N-acetylglucosamine 6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3
• UniProt Protein Name: Carbohydrate sulfotransferase 4
• Protein Family: Carbohydrate sulfotransferase
• UniProt Gene Name: CHST4
• UniProt Synonym Gene Names: GST-3; HEC-GlcNAc6ST; LSST; GlcNAc6ST-2; Gn6st-2
• UniProt Entry Name: CHST4_HUMAN

NCBI Description

This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Uniprot Description

CHST4: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.

Protein type: Membrane protein, integral; EC 2.8.2.-; Glycan Metabolism - keratan sulfate biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: intrinsic to Golgi membrane; integral to membrane; trans-Golgi network

Molecular Function: sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity

Biological Process: sulfur metabolic process; cell-cell signaling; protein amino acid sulfation; N-acetylglucosamine metabolic process; carbohydrate metabolic process; immune response; cell adhesion; inflammatory response; leukocyte tethering or rolling; cell motility