Bovine AP-4 complex subunit sigma-1 (AP4S1) ELISA Kit | AP4S1 elisa kit
Bovine AP-4 complex subunit sigma-1 (AP4S1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]
Uniprot Description
AP4S1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4S1 are the cause of cerebral palsy spastic quadriplegic type 6 (CPSQ6). CPSQ6 is a neurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. Belongs to the adaptor complexes small subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: Golgi apparatus; coated pit
Molecular Function: transporter activity; protein transporter activity
Biological Process: protein transport
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Product Notes
The Bovine AP4S1 ap4s1 (Catalog #AAA7230988) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7230988 ELISA Kit recognizes Bovine AP4S1. It is sometimes possible for the material contained within the vial of "AP-4 complex subunit sigma-1 (AP4S1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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