BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Recombinant Protein | BNI3L recombinant protein

Recombinant Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Cat. Num. AAA9422201

• Gene Names: BNIP3L; NIX; BNIP3a
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; Recombinant Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BNI3L recombinant protein

• Host: Yeast
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-219aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

NCBI and Uniprot Product Information

• NCBI GI #: 1060099158
• NCBI GeneID: 665
• NCBI Accession #: NP_001317420.1
• NCBI GenBank Nucleotide #: NM_001330491.1
• UniProt Accession #: O60238; Q5JW63; Q8NF87; B0AZS9
• Molecular Weight: 25.93kD
• NCBI Official Full Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2
• NCBI Official Synonym Full Names: BCL2 interacting protein 3 like
• NCBI Official Symbol: BNIP3L
• NCBI Official Synonym Symbols: NIX; BNIP3a
• NCBI Protein Information: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• UniProt Protein Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• Protein Family: BCL2/adenovirus E1B 19 kDa protein-interacting protein
• UniProt Gene Name: BNIP3L
• UniProt Synonym Gene Names: BNIP3A; BNIP3H; NIX; NIP3L

NCBI Description

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

Uniprot Description

BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: endoplasmic reticulum; intrinsic to membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear speck

Molecular Function: identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: defense response to virus; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; regulation of apoptosis