Bone morphogenetic protein receptor type-1B (Bmpr1b) Recombinant Protein | Bmpr1b recombinant protein

Recombinant Mouse Bone morphogenetic protein receptor type-1B (Bmpr1b)

• Gene Names: Bmpr1b; Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a; AI385617; AV355320
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bone morphogenetic protein receptor type-1B (Bmpr1b); Recombinant Mouse Bone morphogenetic protein receptor type-1B (Bmpr1b); Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; EC=2.7.11.30; Activin receptor-like kinase 6; ALK-6; Serine/threonine-protein kinase receptor R6; SKR6; CD_antigen=; CDw293; Bmpr1b recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 14-126
• Sequence: KKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKDRDFVD GPIHHK
• Sequence Length: 113

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 469608399
• NCBI GeneID: 12167
• NCBI Accession #: NP_001264145.1
• NCBI GenBank Nucleotide #: NM_001277216.1
• UniProt Accession #: P36898; Q3TRF2
• Molecular Weight: 56,944 Da
• NCBI Official Full Name: bone morphogenetic protein receptor type-1B isoform a
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor, type 1B
• NCBI Official Symbol: Bmpr1b
• NCBI Official Synonym Symbols: Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a; AI385617; AV355320
• NCBI Protein Information: bone morphogenetic protein receptor type-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine-protein kinase receptor R6
• UniProt Protein Name: Bone morphogenetic protein receptor type-1B
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: Bmpr1b
• UniProt Synonym Gene Names: Acvrlk6; BMP type-1B receptor; BMPR-1B; ALK-6; SKR6
• UniProt Entry Name: BMR1B_MOUSE

NCBI Description

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: membrane; integral to membrane

Molecular Function: metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transferase activity, transferring phosphorus-containing groups; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: camera-type eye development; positive regulation of bone mineralization; estrogen biosynthetic process; protein amino acid phosphorylation; limb morphogenesis; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; transforming growth factor beta receptor signaling pathway; cartilage development; transmembrane receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; ovarian cumulus expansion; cell differentiation; positive regulation of cell differentiation; skeletal development; phosphorylation; cartilage condensation; retinal ganglion cell axon guidance