Bone Morphogenetic Protein 6 (BMP6) Recombinant Protein | BMP6 recombinant protein

Recombinant Bone Morphogenetic Protein 6 (BMP6)

Cat. Num. AAA2009587

• Gene Names: BMP6; VGR; VGR1
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Bone Morphogenetic Protein 6 (BMP6); Recombinant Bone Morphogenetic Protein 6 (BMP6); BMP6 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGS-SASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH
• Sequence Length: 513

• Applicable Applications for BMP6 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Ser375~His513 (Accession # P22004) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 4502425
• NCBI GeneID: 654
• NCBI Accession #: NP_001709.1
• NCBI GenBank Nucleotide #: NM_001718.4
• UniProt Accession #: P22004; Q5TCP3
• Molecular Weight: 16.9kDa
• NCBI Official Full Name: bone morphogenetic protein 6 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 6
• NCBI Official Symbol: BMP6
• NCBI Official Synonym Symbols: VGR; VGR1
• NCBI Protein Information: bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)
• UniProt Protein Name: Bone morphogenetic protein 6
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP6
• UniProt Synonym Gene Names: VGR; BMP-6; VG-1-R; VGR-1
• UniProt Entry Name: BMP6_HUMAN

NCBI Description

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Uniprot Description

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; regulation of apoptosis; BMP signaling pathway; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; skeletal development; response to iron ion; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; eye development; positive regulation of protein secretion; cartilage development; regulation of MAPKKK cascade; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth