Biliverdin Reductase B Recombinant Protein | BLVRB recombinant protein
Recombinant Human Biliverdin Reductase B
Gene Names
BLVRB; FLR; BVRB; SDR43U1; HEL-S-10
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
Biliverdin Reductase B; Recombinant Human Biliverdin Reductase B; BLVRB Human; Biliverdin Reductase B Human Recombinant; FLR; BVRB; SDR43U1; MGC117413; BLVRB; Flavin reductase; FR; NADPH-dependent diaphorase; NADPH-flavin reductase; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; BLVRB recombinant protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The protein contains 20mM Tris-HCl buffer pH 8.5, 10% glycerol, and 1mM DTT.
Sterile filtered colorless solution.
Sterile filtered colorless solution.
Sequence
MAVKKIAIFG ATGQTGLTTL AQAVQAGYEV TVLVRDSSRL PSEGPRPAHV VVGDVLQAAD VDKTVAGQDA VIVLLGTRND LSPTTVMSEG ARNIVAAMKA HGVDKVVACT SAFLLWDPTK VPPRLQAVTD DHIRMHKVLR ESGLKYVAVM PPHIGDQPLT GAYTVTLDGR GPSRVISKHD LGHFMLRCLT TDEYDGHSTY PSHQYQ
Sequence Length
206
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Related Product Information for BLVRB recombinant protein
Description: BLVRB Human Recombinant amino produced in E Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids having a molecular mass of 22.1 kDa.The BLVRB is purified by proprietary chromatographic techniques.
Introduction: BLVRB (EC 1.3.1.24) catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. BLVRB is involved in protecting cells from oxidative damage or in regulating iron metabolism. BLVRB converts biliverdin to bilirubin in the liver, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRB plays a role as in human erythrocytic heme catabolic pathway and most mammalian species. Biliverdin reductase is abundantly expressed in kidney, spleen, liver and brain as well as at lower levels in the thymus and minimal levels being detected in testis.
Introduction: BLVRB (EC 1.3.1.24) catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. BLVRB is involved in protecting cells from oxidative damage or in regulating iron metabolism. BLVRB converts biliverdin to bilirubin in the liver, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRB plays a role as in human erythrocytic heme catabolic pathway and most mammalian species. Biliverdin reductase is abundantly expressed in kidney, spleen, liver and brain as well as at lower levels in the thymus and minimal levels being detected in testis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
22,119 Da
NCBI Official Full Name
flavin reductase (NADPH)
NCBI Official Synonym Full Names
biliverdin reductase B
NCBI Official Symbol
BLVRB
NCBI Official Synonym Symbols
FLR; BVRB; SDR43U1; HEL-S-10
NCBI Protein Information
flavin reductase (NADPH); flavin reductase (NADPH); BVR-B; FR; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; biliverdin reductase B (flavin reductase (NADPH)); biliverdin-IX beta-reductase; epididymis secretory protein Li 10; green heme-binding protein; short chain dehydrogenase/reductase family 43U, member 1
UniProt Protein Name
Flavin reductase (NADPH)
UniProt Gene Name
BLVRB
UniProt Synonym Gene Names
FLR; FR; BVR-B; GHBP; FLR
UniProt Entry Name
BLVRB_HUMAN
NCBI Description
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Uniprot Description
BLVRB: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Protein type: EC 1.5.1.30; Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24
Chromosomal Location of Human Ortholog: 19q13.1-q13.2
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: flavin reductase activity; biliverdin reductase activity
Biological Process: heme catabolic process; porphyrin metabolic process
Research Articles on BLVRB
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Product Notes
The BLVRB blvrb (Catalog #AAA143858) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MAVKKIAIFG ATGQTGLTTL AQAVQAGYEV TVLVRDSSRL PSEGPRPAHV VVGDVLQAAD VDKTVAGQDA VIVLLGTRND LSPTTVMSEG ARNIVAAMKA HGVDKVVACT SAFLLWDPTK VPPRLQAVTD DHIRMHKVLR ESGLKYVAVM PPHIGDQPLT GAYTVTLDGR GPSRVISKHD LGHFMLRCLT TDEYDGHSTY PSHQYQ. It is sometimes possible for the material contained within the vial of "Biliverdin Reductase B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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