ZNF385A blocking peptide
ZNF385A Antibody (N-term) Blocking Peptide
Gene Names
ZNF385A; HZF; RZF; ZFP385; ZNF385
Synonyms
ZNF385A; ZNF385A Antibody (N-term) Blocking Peptide; Zinc finger protein 385A; Hematopoietic zinc finger protein; Retinal zinc finger protein; HZF; RZF; ZNF385; ZNF385A blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
386
Cellular Location
Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note: Detected in dendrites of Purkinje cells and hippocampal neurons.
Tissue Location
Expressed predominantly in the retina.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ZNF385A blocking peptide
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
32,291 Da
NCBI Official Full Name
Zinc finger protein 385A
NCBI Official Synonym Full Names
zinc finger protein 385A
NCBI Official Symbol
ZNF385A
NCBI Official Synonym Symbols
HZF; RZF; ZFP385; ZNF385
NCBI Protein Information
zinc finger protein 385A
UniProt Protein Name
Zinc finger protein 385A
Protein Family
UniProt Gene Name
ZNF385A
UniProt Synonym Gene Names
HZF; RZF; ZNF385
UniProt Entry Name
Z385A_HUMAN
NCBI Description
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]
Uniprot Description
ZNF385: May be involved in transcriptional regulation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cell soma; dendrite; nuclear chromatin; nucleoplasm
Molecular Function: mRNA 3'-UTR binding; p53 binding
Biological Process: apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of fat cell differentiation; response to DNA damage stimulus
Research Articles on ZNF385A
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Product Notes
The ZNF385A znf385a (Catalog #AAA9222878) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZNF385A, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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