ZBP-89 blocking peptide

ZBP-89 (E84) Peptide

Cat. Num. AAA3002710

• Applications: Blocking
• Purity: Synthetic peptide ZBP-89 (E84). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: ZBP-89; ZBP-89 (E84) Peptide; ZNF148; Zinc finger protein 148; ZBP-89 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002709 ZBP-89 (E84) pAb.
• Purity/Purification: Synthetic peptide ZBP-89 (E84). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 794

• Applicable Applications for ZBP-89 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for ZBP-89 blocking peptide

ZBP-89, also known as BFCOL1, BERF1 and ZNF 148, is a zinc finger transcription factor that is universally expressed. ZBP-89, a Kruppel-like repressor protein, is the silencer element binding factor for Vimentin. ZBP-89 has been shown to bind to GC-rich DNA elements in promoters for gastrin, ornithine decarboxylase and the cyclin-dependent kinase inhibitor p21 (also designated Cip1 or WAF1). ZBP-89 expression is induced by trans-retinoic acid or butyrate, which also induces terminal differentiation of colon cancer cells. ZBP-89 cooperates with histone acetyltransferase coactivator p300 in the regulation of p21, a cyclin-dependent kinase inhibitor whose associated gene is a target gene of p53. ZBP-89 also regulates cell proliferation, in part, through its ability to directly bind the p53 protein and retard its nuclear export. Elevated levels of ZBP-89 induce growth arrest and apoptosis in human gastrointestinal cells.

NCBI and Uniprot Product Information

• NCBI GI #: 145386566
• NCBI Accession #: NP_068799.2
• NCBI GenBank Nucleotide #: NP_068799.2
• UniProt Accession #: Q9UQR1
• NCBI Official Full Name: zinc finger protein 148 isoform a
• UniProt Protein Name: Zinc finger protein 148
• UniProt Gene Name: ZNF148
• UniProt Synonym Gene Names: ZBP89
• UniProt Entry Name: ZN148_HUMAN

Uniprot Description

ZNF148: a transcription factor. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: nucleoplasm; Golgi apparatus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding

Biological Process: transcription from RNA polymerase II promoter; substantia nigra development; gamete generation; cellular defense response; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent