WIBG blocking peptide
WIBG Antibody (N-term) Blocking peptide
Gene Names
PYM1; PYM; WIBG
Synonyms
WIBG; WIBG Antibody (N-term) Blocking peptide; Partner of Y14 and mago; Protein wibg homolog; PYM; WIBG blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
204
Cellular Location
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note: Shuttles between the nucleus and the cytoplasm Nuclear export is mediated by XPO1/CRM1
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for WIBG blocking peptide
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
22,705 Da
NCBI Official Full Name
Partner of Y14 and mago
NCBI Official Synonym Full Names
PYM homolog 1, exon junction complex associated factor
NCBI Official Symbol
PYM1
NCBI Official Synonym Symbols
PYM; WIBG
NCBI Protein Information
partner of Y14 and mago
UniProt Protein Name
Partner of Y14 and mago
UniProt Gene Name
PYM1
UniProt Entry Name
PYM1_HUMAN
Uniprot Description
WIBG: a conserved protein of unknown function. A potential RNA-binding protein.
Protein type: RNA-binding; Nucleolus; Translation
Chromosomal Location of Human Ortholog: 12q13.2
Molecular Function: protein binding; ribosome binding
Biological Process: mRNA catabolic process, nonsense-mediated decay; positive regulation of translation
Research Articles on WIBG
Similar Products
Product Notes
The WIBG pym1 (Catalog #AAA9217809) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "WIBG, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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