WDR34 blocking peptide

WDR34 Antibody (Center) Blocking peptide

• Gene Names: WDR34; DIC5; FAP133; SRTD11; bA216B9.3
• Synonyms: WDR34; WDR34 Antibody (Center) Blocking peptide; WD repeat-containing protein 34; WDR34 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 536

• Cellular Location: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note: Concentrates around the centrioles and basal bodies also showing axonemal staining
• Tissue Location: Expressed in several cell lines (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for WDR34 blocking peptide

Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

NCBI and Uniprot Product Information

• NCBI GI #: 88985038
• NCBI GeneID: 89891
• UniProt Accession #: Q96EX3; Q5VXV4; Q9BV46
• Molecular Weight: 57,801 Da
• NCBI Official Full Name: WD repeat-containing protein 34
• NCBI Official Synonym Full Names: WD repeat domain 34
• NCBI Official Symbol: WDR34
• NCBI Official Synonym Symbols: DIC5; FAP133; SRTD11; bA216B9.3
• NCBI Protein Information: WD repeat-containing protein 34
• UniProt Protein Name: WD repeat-containing protein 34
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR34
• UniProt Entry Name: WDR34_HUMAN

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]

Uniprot Description

WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: axoneme; centriole; cytoplasm

Molecular Function: protein binding

Disease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly