VPS54 blocking peptide

VPS54 Antibody (Center) Blocking peptide

• Gene Names: VPS54; WR; HCC8; SLP-8p; VPS54L; hVps54L; PPP1R164
• Synonyms: VPS54; VPS54 Antibody (Center) Blocking peptide; Vacuolar protein sorting-associated protein 54; Hepatocellular carcinoma protein 8; Tumor antigen HOM-HCC-8; Tumor antigen SLP-8p; HCC8; VPS54 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 977

• Cellular Location: Golgi apparatus, trans-Golgi network
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VPS54 blocking peptide

May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.

NCBI and Uniprot Product Information

• NCBI GI #: 82583721
• NCBI GeneID: 51542
• UniProt Accession #: Q9P1Q0; Q5VIR5; Q86YF7; Q8N6G3; Q9NPV0; Q9NT07; Q9NUJ0
• Molecular Weight: 15,982 Da
• NCBI Official Full Name: Vacuolar protein sorting-associated protein 54
• NCBI Official Synonym Full Names: VPS54, GARP complex subunit
• NCBI Official Symbol: VPS54
• NCBI Official Synonym Symbols: WR; HCC8; SLP-8p; VPS54L; hVps54L; PPP1R164
• NCBI Protein Information: vacuolar protein sorting-associated protein 54
• UniProt Protein Name: Vacuolar protein sorting-associated protein 54
• UniProt Gene Name: VPS54
• UniProt Synonym Gene Names: HCC8
• UniProt Entry Name: VPS54_HUMAN

NCBI Description

This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]

Uniprot Description

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).