VPS52 blocking peptide

VPS52 Antibody (C-term) Blocking peptide

• Gene Names: VPS52; ARE1; SAC2; SACM2L; dJ1033B10.5
• Synonyms: VPS52; VPS52 Antibody (C-term) Blocking peptide; Vacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein; SACM2L; VPS52 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 723

• Cellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VPS52 blocking peptide

May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.

NCBI and Uniprot Product Information

• NCBI GI #: 74750887
• NCBI GeneID: 6293
• UniProt Accession #: Q8N1B4; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q9NPT5; A2BF38; B0UZZ4; B4DNI9
• Molecular Weight: 68,496 Da
• NCBI Official Full Name: Vacuolar protein sorting-associated protein 52 homolog
• NCBI Official Synonym Full Names: VPS52, GARP complex subunit
• NCBI Official Symbol: VPS52
• NCBI Official Synonym Symbols: ARE1; SAC2; SACM2L; dJ1033B10.5
• NCBI Protein Information: vacuolar protein sorting-associated protein 52 homolog
• UniProt Protein Name: Vacuolar protein sorting-associated protein 52 homolog
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS52
• UniProt Synonym Gene Names: SACM2L
• UniProt Entry Name: VPS52_HUMAN

NCBI Description

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

VPS52: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Belongs to the VPS52 family.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi apparatus; membrane; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network membrane

Molecular Function: protein binding; syntaxin binding

Biological Process: endocytic recycling; lysosomal transport