VAMP4 blocking peptide

VAMP4 Blocking Peptide (Center)

• Gene Names: VAMP4; VAMP-4; VAMP24
• Synonyms: VAMP4; VAMP4 Blocking Peptide (Center); Vesicle-associated membrane protein 4; VAMP-4; VAMP4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 76-90 of HUMAN VAMP4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 141

• Cellular Location: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note: Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VAMP4 blocking peptide

Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

NCBI and Uniprot Product Information

• NCBI GI #: 42544207
• NCBI GeneID: 8674
• NCBI Accession #: NP_003753.2
• NCBI GenBank Nucleotide #: NM_003762.4
• UniProt Accession #: O75379; Q96IY9; Q96J20; Q9UEL7; A2IDD8
• Molecular Weight: 16,241 Da
• NCBI Official Full Name: vesicle-associated membrane protein 4 isoform 1
• NCBI Official Synonym Full Names: vesicle associated membrane protein 4
• NCBI Official Symbol: VAMP4
• NCBI Official Synonym Symbols: VAMP-4; VAMP24
• NCBI Protein Information: vesicle-associated membrane protein 4
• UniProt Protein Name: Vesicle-associated membrane protein 4
• Protein Family: Vesicle-associated membrane protein
• UniProt Gene Name: VAMP4
• UniProt Synonym Gene Names: VAMP-4
• UniProt Entry Name: VAMP4_HUMAN

NCBI Description

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

Uniprot Description

VAMP4: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. Belongs to the synaptobrevin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24-q25

Cellular Component: cell surface; endosome; Golgi apparatus; Golgi membrane; lysosome; SNARE complex; trans-Golgi network membrane; transport vesicle

Molecular Function: protein binding; SNAP receptor activity; SNARE binding

Biological Process: ER to Golgi vesicle-mediated transport; exocytosis; Golgi to plasma membrane protein transport; microtubule cytoskeleton organization and biogenesis