USP3 blocking peptide

USP3 Antibody (C-term) Blocking Peptide

• Gene Names: USP3; UBP; SIH003
• Synonyms: USP3; USP3 Antibody (C-term) Blocking Peptide; Ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3; USP3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human USP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 520

• Cellular Location: Nucleus. Note: Localizes preferentially with monoubiquitinated H2A to chromatin
• Tissue Location: Expressed in all tissues examined, with strongest expression in pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for USP3 blocking peptide

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.

NCBI and Uniprot Product Information

• NCBI GI #: 205371844
• NCBI GeneID: 9960
• UniProt Accession #: Q9Y6I4; Q8WVD0; B4DVU5; F5H1A6
• Molecular Weight: 53,743 Da
• NCBI Official Full Name: Ubiquitin carboxyl-terminal hydrolase 3
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 3
• NCBI Official Symbol: USP3
• NCBI Official Synonym Symbols: UBP; SIH003
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 3
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 3
• UniProt Gene Name: USP3
• UniProt Entry Name: UBP3_HUMAN

Uniprot Description

USP3: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. Belongs to the peptidase C19 family. USP3 subfamily.

Protein type: Ubiquitin-specific protease; Protease; Ubiquitin conjugating system; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 15q22.3

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear chromatin; nucleus

Molecular Function: histone binding

Biological Process: DNA repair; histone deubiquitination; mitotic cell cycle; regulation of protein stability