UNC5B blocking peptide

UNC5B Blocking Peptide (Center)

• Gene Names: UNC5B; UNC5H2; p53RDL1
• Synonyms: UNC5B; UNC5B Blocking Peptide (Center); Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1; P53RDL1; UNC5H2; UNC5B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 507-521 of HUMAN UNC5B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 945

• Cellular Location: Membrane; Single-pass type I membrane protein Note: Associated with lipid raft
• Tissue Location: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for UNC5B blocking peptide

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

NCBI and Uniprot Product Information

• NCBI GI #: 54036589
• NCBI GeneID: 219699
• UniProt Accession #: Q8IZJ1; Q5T3R9; Q5T3S0; Q86SN3; Q8N1Y2; Q9H9F3
• Molecular Weight: 102,434 Da
• NCBI Official Full Name: Netrin receptor UNC5B
• NCBI Official Synonym Full Names: unc-5 netrin receptor B
• NCBI Official Symbol: UNC5B
• NCBI Official Synonym Symbols: UNC5H2; p53RDL1
• NCBI Protein Information: netrin receptor UNC5B
• UniProt Protein Name: Netrin receptor UNC5B
• Protein Family: Netrin receptor
• UniProt Gene Name: UNC5B
• UniProt Synonym Gene Names: p53RDL1
• UniProt Entry Name: UNC5B_HUMAN

NCBI Description

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

UNC5B: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 10q22.1

Molecular Function: protein binding

Biological Process: negative regulation of neuron apoptosis; positive regulation of phosphoinositide 3-kinase cascade