TYRO3 blocking peptide

TYRO3 Antibody Blocking Peptide

• Gene Names: TYRO3; BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
• Synonyms: TYRO3; TYRO3 Antibody Blocking Peptide; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; BYK; DTK; RSE; SKY; TIF; TYRO3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the region of human TYRO3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 890

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Abundant in the brain and lower levels in other tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TYRO3 blocking peptide

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

NCBI and Uniprot Product Information

• NCBI GI #: 27597078
• NCBI GeneID: 7301
• NCBI Accession #: NP_006284
• NCBI GenBank Nucleotide #: NM_006293.3
• UniProt Accession #: Q06418; O14953; Q86VR3
• Molecular Weight: 96,905 Da
• NCBI Official Full Name: tyrosine-protein kinase receptor TYRO3
• NCBI Official Synonym Full Names: TYRO3 protein tyrosine kinase
• NCBI Official Symbol: TYRO3
• NCBI Official Synonym Symbols: BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
• NCBI Protein Information: tyrosine-protein kinase receptor TYRO3
• UniProt Protein Name: Tyrosine-protein kinase receptor TYRO3
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: TYRO3
• UniProt Synonym Gene Names: BYK; DTK; RSE; SKY; TIF
• UniProt Entry Name: TYRO3_HUMAN

NCBI Description

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Uniprot Description

Tyro3: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TUB, TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. Abundant in the brain and lower levels in other tissues. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Protein type: Membrane protein, integral; EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Axl family

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: endoplasmic reticulum membrane; nuclear envelope; nucleus

Molecular Function: phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity

Biological Process: apoptotic cell clearance; forebrain cell migration; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of neuron apoptosis; negative regulation of toll-like receptor signaling pathway; ovulation cycle; platelet activation; protein amino acid autophosphorylation; protein kinase B signaling cascade; secretion by cell; spermatogenesis