TSPYL2 blocking peptide

TSPYL2 Blocking Peptide (Center)

• Gene Names: TSPYL2; CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
• Synonyms: TSPYL2; TSPYL2 Blocking Peptide (Center); Testis-specific Y-encoded-like protein 2; TSPY-like protein 2; Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79; CDA1; DENTT; TSPX; TSPYL2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 693

• Cellular Location: Nucleus. Cytoplasm Note: Enriched in transcriptionally active regions of chromatin in neurons.
• Tissue Location: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TSPYL2 blocking peptide

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

NCBI and Uniprot Product Information

• NCBI GI #: 74752604
• NCBI GeneID: 64061
• UniProt Accession #: Q9H2G4; O94799; Q96DG7; Q9BZW6
• Molecular Weight: 79,435 Da
• NCBI Official Full Name: Testis-specific Y-encoded-like protein 2
• NCBI Official Synonym Full Names: TSPY like 2
• NCBI Official Symbol: TSPYL2
• NCBI Official Synonym Symbols: CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
• NCBI Protein Information: testis-specific Y-encoded-like protein 2
• UniProt Protein Name: Testis-specific Y-encoded-like protein 2
• Protein Family: Testis-specific Y-encoded-like protein
• UniProt Gene Name: TSPYL2
• UniProt Synonym Gene Names: CDA1; DENTT; TSPX; TSPY-like protein 2; CTCL-associated antigen se20-4; NP79
• UniProt Entry Name: TSYL2_HUMAN

NCBI Description

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Uniprot Description

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Transcription regulation; DNA replication

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: centrosome; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane

Biological Process: negative regulation of cell growth; negative regulation of DNA replication; regulation of protein kinase activity