TSG101 blocking peptide

TSG101 Blocking Peptide

Cat. Num. AAA5400664

• Gene Names: TSG101; TSG10; VPS23
• Applications: Immunodepletion, Immunocompetition
• Synonyms: TSG101; TSG101 Blocking Peptide; Antigenic Blocking Peptide Tumor susceptibility gene 101 protein Antibody; ESCRT I complex subunit TSG101 antibody; TS101_HUMAN antibody; TSG 10 antibody; TSG 101 antibody; Tumor susceptibility gene 10 antibody; Tumor susceptibility gene 101 antibody; Tumor susceptibility protein antibody; Tumor susceptibility protein isoform 3 antibody; VPS23 antibody; TSG101 blocking peptide

• Sequence Length: 390

• Applicable Applications for TSG101 blocking peptide: Immunodepletion, Immunocompetition
• Molecular Function: calcium-dependent protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; protein homodimerization activity; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding
• Subcellular Location: Cytoplasm; Membrane; Peripheral membrane protein; Nucleus; Late endosome membrane; Peripheral membrane protein
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for TSG101 blocking peptide

Overview: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Peptide Description: Synthetic peptide taken within amino acid region 330-390 on Tumor susceptibility gene 101 protein.

Expression: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

NCBI and Uniprot Product Information

• NCBI GI #: 5454140
• NCBI GeneID: 7251
• NCBI Accession #: NP_006283.1
• NCBI GenBank Nucleotide #: NM_006292.3
• UniProt Accession #: Q99816; Q9BUM5
• Molecular Weight: 31,732 Da
• NCBI Official Full Name: tumor susceptibility gene 101 protein
• NCBI Official Synonym Full Names: tumor susceptibility 101
• NCBI Official Symbol: TSG101
• NCBI Official Synonym Symbols: TSG10; VPS23
• NCBI Protein Information: tumor susceptibility gene 101 protein
• UniProt Protein Name: Tumor susceptibility gene 101 protein
• Protein Family: Tumor susceptibility gene 101 protein
• UniProt Gene Name: TSG101

NCBI Description

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).