TNFSF18 blocking peptide

TNFSF18 Antibody (Center) Blocking Peptide

• Gene Names: TNFSF18; TL6; AITRL; GITRL; TNLG2A; hGITRL
• Synonyms: TNFSF18; TNFSF18 Antibody (Center) Blocking Peptide; Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; GITRL; TL6; TNFSF18 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 199

• Cellular Location: Cell membrane; Single-pass type II membrane protein
• Tissue Location: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TNFSF18 blocking peptide

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 325511353
• NCBI GeneID: 8995
• UniProt Accession #: Q9UNG2; O95852; Q6ISV1; A9IQG8
• Molecular Weight: 22,724 Da
• NCBI Official Full Name: Tumor necrosis factor ligand superfamily member 18
• NCBI Official Synonym Full Names: tumor necrosis factor superfamily member 18
• NCBI Official Symbol: TNFSF18
• NCBI Official Synonym Symbols: TL6; AITRL; GITRL; TNLG2A; hGITRL
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 18
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 18
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF18
• UniProt Synonym Gene Names: AITRL; GITRL; TL6; AITRL; hGITRL
• UniProt Entry Name: TNF18_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: cell surface; plasma membrane

Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of NF-kappaB transcription factor; cell-cell signaling; negative regulation of apoptosis; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of T cell proliferation; signal transduction; T cell proliferation during immune response; tumor necrosis factor-mediated signaling pathway