TMIGD2 blocking peptide

TMIGD2 Blocking Peptide (Center)

• Gene Names: TMIGD2; CD28H; IGPR1; IGPR-1
• Synonyms: TMIGD2; TMIGD2 Blocking Peptide (Center); Transmembrane and immunoglobulin domain-containing protein 2; CD28 homolog; Immunoglobulin and proline-rich receptor 1; IGPR-1; CD28H; IGPR1; TMIGD2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 134-147 of HUMAN TMIGD2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 282

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TMIGD2 blocking peptide

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

NCBI and Uniprot Product Information

• NCBI GI #: 281306838
• NCBI GeneID: 126259
• NCBI Accession #: NP_653216.2
• NCBI GenBank Nucleotide #: NM_144615.2
• UniProt Accession #: Q96BF3; Q6UW59
• Molecular Weight: 30,319 Da
• NCBI Official Full Name: transmembrane and immunoglobulin domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: transmembrane and immunoglobulin domain containing 2
• NCBI Official Symbol: TMIGD2
• NCBI Official Synonym Symbols: CD28H; IGPR1; IGPR-1
• NCBI Protein Information: transmembrane and immunoglobulin domain-containing protein 2
• UniProt Protein Name: Transmembrane and immunoglobulin domain-containing protein 2
• Protein Family: Transmembrane and immunoglobulin domain-containing protein
• UniProt Gene Name: TMIGD2
• UniProt Synonym Gene Names: CD28H; IGPR1; IGPR-1
• UniProt Entry Name: TMIG2_HUMAN

Uniprot Description

IGPR-1: Plays a role in cell-cell interaction, cell migration, and angiogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular space

Molecular Function: coreceptor activity; protein binding

Biological Process: immune response; immunoglobulin production; positive regulation of activated T cell proliferation; positive regulation of angiogenesis; positive regulation of cytokine production; T cell costimulation