TLX3 blocking peptide

TLX3 Peptide

Cat. Num. AAA153847

• Gene Names: TLX3; RNX; HOX11L2
• Applications: Blocking (BL)
• Synonyms: TLX3; TLX3 Peptide; RNX; HOX11L2; T-cell leukemia homeobox protein 3; Homeobox protein Hox-11L2; T-cell leukemia homeobox 3; TLX3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 291

• Applicable Applications for TLX3 blocking peptide: Blocking (BL)
• Application Notes: TLX3 peptide is used for blocking the activity of TLX3 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acid peptide near the amino terminus of human TLX3.
• Preparation and Storage: Store TLX3 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 50355978
• NCBI GeneID: 30012
• NCBI Accession #: NP_066305
• NCBI GenBank Nucleotide #: NM_021025.2
• UniProt Accession #: O43711; Q96AD3
• Molecular Weight: 31,867 Da
• NCBI Official Full Name: T-cell leukemia homeobox protein 3
• NCBI Official Synonym Full Names: T-cell leukemia homeobox 3
• NCBI Official Symbol: TLX3
• NCBI Official Synonym Symbols: RNX; HOX11L2
• NCBI Protein Information: T-cell leukemia homeobox protein 3; homeo box 11-like 2; homeobox protein Hox-11L2; T-cell leukemia, homeobox 3
• UniProt Protein Name: T-cell leukemia homeobox protein 3
• Protein Family: T-cell leukemia homeobox protein
• UniProt Gene Name: TLX3
• UniProt Synonym Gene Names: HOX11L2
• UniProt Entry Name: TLX3_HUMAN

NCBI Description

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]

Uniprot Description

TLX3:

Protein type: Transcription factor; Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: negative regulation of neuron differentiation; central nervous system development; regulation of transcription, DNA-dependent; neuron migration; neuron fate specification; neurological control of breathing; respiratory gaseous exchange