Tlr6 blocking peptide

Mouse TLR6 Antibody (N-term) Blocking Peptide

• Synonyms: TLR6; Mouse TLR6 Antibody (N-term) Blocking Peptide; Toll-like receptor 6; CD286; Tlr6; Tlr6 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human Mouse TLR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 806

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note: Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis
• Tissue Location: Detected in thymus, spleen, ovary and lung.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tlr6 blocking peptide

Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

NCBI and Uniprot Product Information

• NCBI GI #: 157057101
• NCBI GeneID: 21899
• NCBI Accession #: NP_035734
• NCBI GenBank Nucleotide #: NM_011604.3
• UniProt Accession #: Q9EPW9; Q9WTQ4
• Molecular Weight: 91,116 Da
• NCBI Official Full Name: toll-like receptor 6
• NCBI Official Synonym Full Names: toll-like receptor 6
• NCBI Official Symbol: Tlr6
• NCBI Protein Information: toll-like receptor 6
• UniProt Protein Name: Toll-like receptor 6
• UniProt Gene Name: Tlr6
• UniProt Entry Name: TLR6_MOUSE

Uniprot Description

TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft

Molecular Function: diacylated lipoprotein binding; protein heterodimerization activity; transmembrane receptor activity

Biological Process: defense response to bacterium; detection of diacylated bacterial lipoprotein; inflammatory response; interleukin-1 beta secretion; microglial cell activation; nitric oxide metabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; response to bacterial lipoprotein; T-helper 1 type immune response; toll-like receptor signaling pathway