TIAM2 blocking peptide

TIAM2 Antibody (N-term) Blocking peptide

• Gene Names: TIAM2; STEF; TIAM-2
• Synonyms: TIAM2; TIAM2 Antibody (N-term) Blocking peptide; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; SIF and TIAM1-like exchange factor; KIAA2016; STEF; TIAM2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of TIAM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1701

• Cellular Location: Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note: Localizes to the plasma membrane in neurites.
• Tissue Location: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TIAM2 blocking peptide

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

NCBI and Uniprot Product Information

• NCBI GI #: 296453025
• NCBI GeneID: 26230
• UniProt Accession #: Q8IVF5; Q6NXN9; Q6ZUP9; Q9UFG6; Q9UKV9; Q9UKW0; B2RP56; C9JZV2
• Molecular Weight: 192,555 Da
• NCBI Official Full Name: T-lymphoma invasion and metastasis-inducing protein 2
• NCBI Official Synonym Full Names: T-cell lymphoma invasion and metastasis 2
• NCBI Official Symbol: TIAM2
• NCBI Official Synonym Symbols: STEF; TIAM-2
• NCBI Protein Information: T-lymphoma invasion and metastasis-inducing protein 2
• UniProt Protein Name: T-lymphoma invasion and metastasis-inducing protein 2
• Protein Family: T-lymphoma invasion and metastasis-inducing protein
• UniProt Gene Name: TIAM2
• UniProt Synonym Gene Names: KIAA2016; STEF; TIAM-2
• UniProt Entry Name: TIAM2_HUMAN

NCBI Description

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (). Activates specifically RAC1, but not CDC42 and RHOA.