TFAP2B blocking peptide

TFAP2B Antibody (C-term) Blocking peptide

• Gene Names: TFAP2B; PDA2; AP-2B; AP2-B
• Synonyms: TFAP2B; TFAP2B Antibody (C-term) Blocking peptide; Transcription factor AP-2-beta; AP2-beta; Activating enhancer-binding protein 2-beta; TFAP2B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of TFAP2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 460

• Cellular Location: Nucleus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TFAP2B blocking peptide

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.

NCBI and Uniprot Product Information

• NCBI GI #: 152031557
• NCBI GeneID: 7021
• UniProt Accession #: Q92481; Q5JYX6; Q9NQ63; Q9NU99; Q9UJI7; Q9Y214; Q9Y3K3
• Molecular Weight: 51,524 Da
• NCBI Official Full Name: Transcription factor AP-2-beta
• NCBI Official Synonym Full Names: transcription factor AP-2 beta
• NCBI Official Symbol: TFAP2B
• NCBI Official Synonym Symbols: PDA2; AP-2B; AP2-B
• NCBI Protein Information: transcription factor AP-2-beta
• UniProt Protein Name: Transcription factor AP-2-beta
• Protein Family: Transcription factor
• UniProt Gene Name: TFAP2B
• UniProt Synonym Gene Names: AP2-beta
• UniProt Entry Name: AP2B_HUMAN

NCBI Description

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Uniprot Description

AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: nucleus

Molecular Function: caspase inhibitor activity; DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity

Biological Process: calcium ion homeostasis; fat cell differentiation; forelimb morphogenesis; glucose homeostasis; glucose metabolic process; hindlimb morphogenesis; kidney development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphate ion homeostasis; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; potassium ion homeostasis; regulation of BMP signaling pathway; regulation of cell differentiation; regulation of insulin secretion; regulation of transcription, DNA-dependent; renal water homeostasis; sodium ion homeostasis; sympathetic nervous system development

Disease: Char Syndrome