Western Blot (WB)
(Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
TCIRG1 blocking peptide
TCIRG1 Peptide
Western Blot (WB)
(Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
NCBI and Uniprot Product Information
NCBI Description
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]
Uniprot Description
TCIRG1: Part of the proton channel of V-ATPases. Seems to be directly involved in T-cell activation. Defects in TCIRG1 are the cause of osteopetrosis autosomal recessive type 1 (OPTB1); also called autosomal recessive Albers-Schonberg disease or infantile malignant osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. The features of OPTB1 are macrocephaly, progressive deafness and blindness, hepatosplenomegaly, and severe anemia beginning in early infancy or in fetal life. Deafness and blindness are generally thought to represent effects of pressure on nerves. Belongs to the V-ATPase 116 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, iron; Energy Metabolism - oxidative phosphorylation; Transporter, ion channel; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: phagocytic vesicle membrane; mitochondrion; integral to plasma membrane; lysosomal membrane; apical plasma membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex
Molecular Function: transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding
Biological Process: vacuolar acidification; interaction with host; ATP synthesis coupled proton transport; proton transport; cellular iron ion homeostasis; positive regulation of cell proliferation; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; cellular defense response; transmembrane transport
Disease: Osteopetrosis, Autosomal Recessive 1
Research Articles on TCIRG1
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Product Notes
The TCIRG1 tcirg1 (Catalog #AAA152543) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TCIRG1 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). TCIRG1 peptide is used for blocking the activity of TCIRG1 antibody. Researchers should empirically determine the suitability of the TCIRG1 tcirg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TCIRG1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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