TAF8 blocking peptide

TAF8 Antibody (Center) Blocking peptide

• Gene Names: TAF8; II; TAF; TBN; TAFII43; TAFII-43
• Synonyms: TAF8; TAF8 Antibody (Center) Blocking peptide; Transcription initiation factor TFIID subunit 8; Protein taube nuss; TBP-associated factor 43 kDa; TBP-associated factor 8; Transcription initiation factor TFIID 43 kDa subunit; TAFII-43; TAFII43; hTAFII43; TBN; TAF8 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of TAF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 310

• Cellular Location: Nucleus. Cytoplasm. Note: Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TAF8 blocking peptide

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 74723384
• NCBI GeneID: 129685
• UniProt Accession #: Q7Z7C8; Q5T0K1; Q8N4R9; Q96M52
• Molecular Weight: 37,411 Da
• NCBI Official Full Name: Transcription initiation factor TFIID subunit 8
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 8
• NCBI Official Symbol: TAF8
• NCBI Official Synonym Symbols: II; TAF; TBN; TAFII43; TAFII-43
• NCBI Protein Information: transcription initiation factor TFIID subunit 8
• UniProt Protein Name: Transcription initiation factor TFIID subunit 8
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF8
• UniProt Synonym Gene Names: TAFII43; TBN; TAFII-43; TAFII43; hTAFII43
• UniProt Entry Name: TAF8_HUMAN

NCBI Description

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TBN: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo. Belongs to the TAF8 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription factor TFIID complex

Molecular Function: protein binding

Biological Process: maintenance of protein localization in nucleus; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; snRNA transcription from RNA polymerase II promoter