SYTL4 blocking peptide

SYTL4 Antibody (N-term) Blocking Peptide

• Gene Names: SYTL4; SLP4
• Synonyms: SYTL4; SYTL4 Antibody (N-term) Blocking Peptide; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin; SYTL4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 671

• Cellular Location: Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SYTL4 blocking peptide

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 317373281
• NCBI GeneID: 94121
• UniProt Accession #: Q96C24; Q5H9J3; Q5JPG8; Q8N9P4; Q9H4R0; Q9H4R1
• Molecular Weight: 39,813 Da
• NCBI Official Full Name: Synaptotagmin-like protein 4
• NCBI Official Synonym Full Names: synaptotagmin like 4
• NCBI Official Symbol: SYTL4
• NCBI Official Synonym Symbols: SLP4
• NCBI Protein Information: synaptotagmin-like protein 4
• UniProt Protein Name: Synaptotagmin-like protein 4
• Protein Family: Synaptotagmin-like protein
• UniProt Gene Name: SYTL4
• UniProt Entry Name: SYTL4_HUMAN

NCBI Description

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

Uniprot Description

SYTL4: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xq21.33

Cellular Component: centrosome; cytoplasm; endosome; extrinsic to membrane; nucleoplasm; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; neurexin binding; phospholipid binding; protein binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; positive regulation of exocytosis; positive regulation of protein secretion; regulation of calcium ion-dependent exocytosis; vesicle fusion