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SYT blocking peptide

SYT (A7) Peptide

Gene Names
SS18; SYT; SSXT
Applications
Blocking
Purity
Synthetic peptide SYT (A7). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Synonyms
SYT; SYT (A7) Peptide; Protein SSXT; Protein SYT; Synovial sarcoma translocated to X chromosome protein; SS18; SSXT; SYT blocking peptide
Ordering
For Research Use Only!
Specificity
This peptide can be used with studies using MBS3002144 SYT (A7) pAb.
Purity/Purification
Synthetic peptide SYT (A7). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Form/Format
1 mg/ml in DI water.
Sequence Length
418
Applicable Applications for SYT blocking peptide
Blocking
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Related Product Information for SYT blocking peptide
The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators. SYT-SSX chimeras are detected in most synovial sarcomas. Synovial sarcomas are responsible for up to 10% of soft issue sarcomas and are histologically characterized as either biphasic or monophasic.Genetic analysis indicates that biphasic synovial sarcomas contain SYT-SSX1 fusions, whereas SYT-SSX2 fusions are found in monophasic synovial sarcomas, providing additional distinguishing characterization of these subtypes.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
protein SSXT isoform 1
NCBI Official Synonym Full Names
SS18 subunit of BAF chromatin remodeling complex
NCBI Official Symbol
SS18
NCBI Official Synonym Symbols
SYT; SSXT
NCBI Protein Information
protein SSXT
UniProt Protein Name
Protein SSXT
UniProt Gene Name
SS18
UniProt Synonym Gene Names
SSXT; SYT
UniProt Entry Name
SSXT_HUMAN

Uniprot Description

SS18: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SS18 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: cytoplasmic microtubule; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: response to drug; transcription, DNA-dependent; cell morphogenesis; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis

Research Articles on SYT

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Product Notes

The SYT ss18 (Catalog #AAA3002145) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SYT can be used in a range of immunoassay formats including, but not limited to, Blocking. Researchers should empirically determine the suitability of the SYT ss18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SYT, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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