STOML2 blocking peptide

STOML2 Blocking Peptide (Center)

• Gene Names: STOML2; SLP-2; HSPC108
• Synonyms: STOML2; STOML2 Blocking Peptide (Center); Stomatin-like protein 2; mitochondrial; SLP-2; EPB72-like protein 2; Paraprotein target 7; Paratarg-7; SLP2; STOML2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 176-189 of HUMAN STOML2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 356

• Cellular Location: Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral membrane protein Membrane raft; Peripheral membrane protein. Note: Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells
• Tissue Location: Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STOML2 blocking peptide

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 7305503
• NCBI GeneID: 30968
• NCBI Accession #: NP_038470.1
• NCBI GenBank Nucleotide #: NM_013442.2
• UniProt Accession #: Q9UJZ1; O60376; Q53G29; Q96FY2; Q9P042; B4E1K7; D3DRN3
• Molecular Weight: 33,337 Da
• NCBI Official Full Name: stomatin-like protein 2, mitochondrial isoform a
• NCBI Official Synonym Full Names: stomatin like 2
• NCBI Official Symbol: STOML2
• NCBI Official Synonym Symbols: SLP-2; HSPC108
• NCBI Protein Information: stomatin-like protein 2, mitochondrial
• UniProt Protein Name: Stomatin-like protein 2, mitochondrial
• Protein Family: Stomatin-like protein
• UniProt Gene Name: STOML2
• UniProt Synonym Gene Names: SLP2; SLP-2; Paratarg-7
• UniProt Entry Name: STML2_HUMAN

Uniprot Description

SLP-2: Belongs to the band 7/mec-2 family.

Protein type: Mitochondrial; Cytoskeletal

Chromosomal Location of Human Ortholog: 9p13.1

Cellular Component: actin cytoskeleton; cytoskeleton; extrinsic to plasma membrane; immunological synapse; lipid raft; mitochondrial inner membrane; mitochondrial intermembrane space; signalosome; T cell receptor complex

Molecular Function: GTPase binding; protein binding; receptor binding

Biological Process: cellular calcium ion homeostasis; interleukin-2 production; mitochondrial ATP synthesis coupled proton transport; mitochondrial calcium ion transport; mitochondrion organization and biogenesis; protein oligomerization; T cell receptor signaling pathway