STAT4 blocking peptide

STAT4 Antibody (C-term) Blocking peptide

• Gene Names: STAT4; SLEB11
• Synonyms: STAT4; STAT4 Antibody (C-term) Blocking peptide; Signal transducer and activator of transcription 4; STAT4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of STAT4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 748

• Cellular Location: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STAT4 blocking peptide

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 6226158
• NCBI GeneID: 6775
• UniProt Accession #: Q14765; Q96NZ6
• Molecular Weight: 85,941 Da
• NCBI Official Full Name: Signal transducer and activator of transcription 4
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 4
• NCBI Official Symbol: STAT4
• NCBI Official Synonym Symbols: SLEB11
• NCBI Protein Information: signal transducer and activator of transcription 4
• UniProt Protein Name: Signal transducer and activator of transcription 4
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT4
• UniProt Entry Name: STAT4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Uniprot Description

STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q32.2-q32.3

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: JAK-STAT cascade

Disease: Systemic Lupus Erythematosus, Susceptibility To, 11