SSR1 blocking peptide

SSR1 Antibody (N-term) Blocking Peptide

• Gene Names: SSR1; TRAPA
• Synonyms: SSR1; SSR1 Antibody (N-term) Blocking Peptide; Translocon-associated protein subunit alpha; TRAP-alpha; Signal sequence receptor subunit alpha; SSR-alpha; TRAPA; SSR1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human SSR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 286

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SSR1 blocking peptide

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

NCBI and Uniprot Product Information

• NCBI GI #: 22261821
• NCBI GeneID: 6745
• UniProt Accession #: P43307; Q53GX2; Q53H19; Q5TAM3; Q6IB43; Q8NBH9; Q96IA2; Q9TNQ8; Q9UN49; A8K685
• Molecular Weight: 29,373 Da
• NCBI Official Full Name: Translocon-associated protein subunit alpha
• NCBI Official Synonym Full Names: signal sequence receptor subunit 1
• NCBI Official Symbol: SSR1
• NCBI Official Synonym Symbols: TRAPA
• NCBI Protein Information: translocon-associated protein subunit alpha
• UniProt Protein Name: Translocon-associated protein subunit alpha
• Protein Family: SWI/SNF and RSC complexes
• UniProt Gene Name: SSR1
• UniProt Synonym Gene Names: TRAPA; TRAP-alpha; SSR-alpha
• UniProt Entry Name: SSRA_HUMAN

NCBI Description

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

SSR1: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. Belongs to the TRAP-alpha family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: cotranslational protein targeting to membrane; positive regulation of cell proliferation