SRD5A3 blocking peptide
SRD5A3 Antibody (C-term) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
Uniprot Description
SRD5A3: Probable polyprenol reductase. Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Probably acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP- dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT). Defects in SRD5A3 are the cause of congenital disorder of glycosylation type 1Q (CDG1Q). It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Defects in SRD5A3 are the cause of Kahrizi syndrome (KHRZ). An autosomal recessive neurodevelopmental disorder characterized by mental retardation, cataracts, coloboma, kyphosis, and coarse facial features. Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
Protein type: EC 1.3.1.94; EC 1.3.1.22; Oxidoreductase; Membrane protein, multi-pass; Lipid Metabolism - androgen and estrogen; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Process: androgen biosynthetic process; dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; dolichyl diphosphate biosynthetic process; polyprenol catabolic process
Disease: Congenital Disorder Of Glycosylation, Type Iq; Kahrizi Syndrome
Research Articles on SRD5A3
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Product Notes
The SRD5A3 srd5a3 (Catalog #AAA9225599) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SRD5A3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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