SOS2 blocking peptide

SOS2 Peptide

Cat. Num. AAA3006236

• Gene Names: SOS2; NS9; SOS-2
• Applications: Blocking
• Purity: Synthetic peptide SOS2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SOS2; SOS2 Peptide; Son of sevenless homolog 2; SOS-2; SOS2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006235 SOS2 pAb.
• Purity/Purification: Synthetic peptide SOS2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1332

• Applicable Applications for SOS2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SOS2 blocking peptide

The superfamily of GTP-binding proteins, of which Ras proteins are prototypes, has been implicated in a broad range of biological activities. Studies have identified a family of guanine nucleotide-releasing factors (GRFs) that activate Ras in mammalian cells and an "adapter" protein (Sem 5/GRB2) that appears to mediate the interaction of GRFs with activated receptor molecules. Ras-GRF p140 promotes nucleotide exchange on Ras p21s but not on other members of the Ras gene superfamily. In addition, three mammalian homologs of the Drosophila Ras-GRF, son of sevenless (Sos), have been described. These include two from mouse, mSos 1 and mSos 2, and one from human, hSos. Vav p95 has been reported to function as a GRF in activation of Ras by the T cell receptor and has been reported to have a domain similar to that of Dbl p115, which is a GRF specific for Cdc42Hs. Subsequent to activation, Ras appears to interact with Raf, thereby activating the MAP kinase phosphorylation pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 154689780
• NCBI GeneID: 6655
• NCBI Accession #: NP_008870.2
• NCBI GenBank Nucleotide #: NP_008870.2
• UniProt Accession #: Q07890
• NCBI Official Full Name: son of sevenless homolog 2
• NCBI Official Synonym Full Names: SOS Ras/Rho guanine nucleotide exchange factor 2
• NCBI Official Symbol: SOS2
• NCBI Official Synonym Symbols: NS9; SOS-2
• NCBI Protein Information: son of sevenless homolog 2
• UniProt Protein Name: Son of sevenless homolog 2
• Protein Family: Son of sevenless
• UniProt Gene Name: SOS2
• UniProt Synonym Gene Names: SOS-2
• UniProt Entry Name: SOS2_HUMAN

NCBI Description

This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]

Uniprot Description

SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.

Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q21

Cellular Component: cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity

Biological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction