SnoN blocking peptide

SnoN (D652) Peptide

Cat. Num. AAA3002364

• Gene Names: SKIL; SNO; SnoA; SnoI; SnoN
• Applications: Blocking
• Purity: Synthetic peptide SnoN (D652). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SnoN; SnoN (D652) Peptide; SKIL; SNO. SnoA. SnoN; SnoN blocking peptide

• Specificity: This peptide can be used with studies using MBS3002363 SnoN (D652) pAb.
• Purity/Purification: Synthetic peptide SnoN (D652). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 638

• Applicable Applications for SnoN blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SnoN blocking peptide

SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity.

NCBI and Uniprot Product Information

• NCBI GI #: 223029420
• NCBI GeneID: 6498
• NCBI Accession #: NP_001138569.1
• NCBI GenBank Nucleotide #: NP_001138569.1
• UniProt Accession #: P12757
• NCBI Official Full Name: ski-like protein isoform 2
• NCBI Official Synonym Full Names: SKI like proto-oncogene
• NCBI Official Symbol: SKIL
• NCBI Official Synonym Symbols: SNO; SnoA; SnoI; SnoN
• NCBI Protein Information: ski-like protein
• UniProt Protein Name: Ski-like protein
• UniProt Gene Name: SKIL
• UniProt Synonym Gene Names: SNO
• UniProt Entry Name: SKIL_HUMAN

NCBI Description

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: nucleoplasm; PML body; protein complex; cytoplasm; acrosome; nucleus

Molecular Function: protein domain specific binding; protein binding; DNA binding; protein complex binding; chromatin binding; SMAD binding; transcription corepressor activity

Biological Process: transcription initiation from RNA polymerase II promoter; skeletal muscle development; transcription, DNA-dependent; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; regulation of apoptosis; negative regulation of cell differentiation; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; spermatogenesis; positive regulation of axonogenesis; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; lymphocyte homeostasis