SNAP23 blocking peptide

SNAP23 Antibody (C-term) Blocking Peptide

• Gene Names: SNAP23; SNAP-23; SNAP23A; SNAP23B; HsT17016
• Synonyms: SNAP23; SNAP23 Antibody (C-term) Blocking Peptide; Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23; SNAP23 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 211

• Cellular Location: Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome Note: Mainly localized to the plasma membrane
• Tissue Location: Ubiquitous. Highest levels where found in placenta
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SNAP23 blocking peptide

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

NCBI and Uniprot Product Information

• NCBI GI #: 6685971
• NCBI GeneID: 8773
• UniProt Accession #: O00161; O00162; Q13602; Q6IAE3
• Molecular Weight: 17,789 Da
• NCBI Official Full Name: Synaptosomal-associated protein 23
• NCBI Official Synonym Full Names: synaptosome associated protein 23
• NCBI Official Symbol: SNAP23
• NCBI Official Synonym Symbols: SNAP-23; SNAP23A; SNAP23B; HsT17016
• NCBI Protein Information: synaptosomal-associated protein 23
• UniProt Protein Name: Synaptosomal-associated protein 23
• Protein Family: Synaptosomal-associated protein
• UniProt Gene Name: SNAP23
• UniProt Synonym Gene Names: SNAP-23
• UniProt Entry Name: SNP23_HUMAN

NCBI Description

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: azurophil granule; cytoplasm; focal adhesion; nucleoplasm; plasma membrane; SNARE complex; specific granule

Molecular Function: protein binding; SNAP receptor activity; syntaxin binding

Biological Process: histamine secretion by mast cell; post-Golgi vesicle-mediated transport; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle priming; vesicle targeting