SMG7 blocking peptide

SMG7 (K548) Peptide

Cat. Num. AAA3002180

• Gene Names: SMG7; EST1C; SGA56M; C1orf16
• Applications: Blocking
• Purity: Synthetic peptide SMG7 (K548). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SMG7; SMG7 (K548) Peptide; C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1C; ever shorter telomeres 1C; FLJ23717; SGA56M; SMG 7; SMG7 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002179 SMG7 (K548) pAb.
• Purity/Purification: Synthetic peptide SMG7 (K548). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1145

• Applicable Applications for SMG7 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SMG7 blocking peptide

In humans, NMD depends on RNA-dependent ATPase and 5' to 3' helicase UPF1, plus six other proteins designated SMG1, SMG5, SMG6, SMG7, UPF2 and UPF3. SMG5, SMG7 and UPF1 localize to cytoplasmic foci called P-bodies, while SMG5, SMG6 and SMG7 target UPF1 for dephosphorylation. SMG7 may also act as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. SMG7 provides a link between the NMD pathway and mRNA degradation machinery by forming a complex with the proteins SMG5 and UPF1, interacting with them via its N-terminal domain, and targeting bound reporter transcripts for decay via its C-terminal domain. SMG7 contains a 14-3-3-like domain, and residues that bind phosphoserine-containing peptides in 14-3-3 proteins are conserved at the equivalent positions in SMG7.

NCBI and Uniprot Product Information

• NCBI GI #: 291327485
• NCBI GeneID: 9887
• NCBI Accession #: NP_001167532.1
• NCBI GenBank Nucleotide #: NP_001167532.1
• UniProt Accession #: Q92540
• NCBI Official Full Name: protein SMG7 isoform 5
• NCBI Official Synonym Full Names: SMG7 nonsense mediated mRNA decay factor
• NCBI Official Symbol: SMG7
• NCBI Official Synonym Symbols: EST1C; SGA56M; C1orf16
• NCBI Protein Information: protein SMG7
• UniProt Protein Name: Protein SMG7
• Protein Family: Protein
• UniProt Gene Name: SMG7
• UniProt Synonym Gene Names: C1orf16; EST1C; KIAA0250; hSMG-7
• UniProt Entry Name: SMG7_HUMAN

NCBI Description

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Uniprot Description

SMG7: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: intermediate filament cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; protein phosphatase 2A binding

Biological Process: mRNA export from nucleus; mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; gene expression